Designing antimicrobial peptides: form follows function

By Christopher D. Fjell, Jan A. Hiss, Robert E. W. Hancock, Gisbert Schneider. Nature reviews. Drug discovery, 2011

1,868 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/42321ee973d5361ddc4f3e720b784bc8520993b6

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In Microbiology

1. Q. Kong
2. Yuchen Huan
3. H. Yi
4. Haijin Mou
5. P. Rondón-Villarreal
6. Daniel Osório
7. D. Ren
8. Rodrigo Torres

In Molecular Biology

1. Q. Kong
2. Yuchen Huan
3. H. Yi
4. Haijin Mou
5. Carolina S. Silva
6. M. O. Santos
7. Payel Das
8. Vijil Chenthamarakshan

Citations in the corpus

• Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields (2020, background): “Extracellular polymeric substances (EPS) are important for biofilms and can enhance the resistance of cells to antibacterial agents (Flemming, 2016).”
• Antimicrobial Peptides (2013, background): “Estimating the structure of an AMP based on its primary sequence [191], then predicting potential mechanism of action and activity is becoming easier with the help of computational approaches [192].”
• PepCVAE: Semi-Supervised Targeted Design of Antimicrobial Peptide Sequences (2018, methodology): “in terms of molecular features, e.g. charge, hydrophobicity (H), and hydrophobic moment (H), which are of particular interest, as they play a key role in determining the membrane binding specificity [Fjell et al., 2012]. The amino acid composition, net positive charge, and hydrophobicity (H) (Fig. 6a”
• Multifunctional Coatings to Simultaneously Promote Osseointegration and Prevent Infection of Orthopaedic Implants (2016, neutral): “AMPs are typically short, amphiphilic, cationic peptides that can interfere with microbial membranes and, upon entry into the cell cytoplasm, intracellular targets [133,134].”
• Peptides: A Package for Data Mining of Antimicrobial Peptides (2015, background): “Multiple research have concluded that the natural biological activities of these peptides are coordinated by a sophisticated modulation of the hydrophobicity, amphipathicity, positive charge and a reduction in the hydrophobic moment (Yeaman and Yount, 2003; Fjell et al., 2012; Matsuzaki, 2009).”
• Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, methodology): “…Agents Margit Mahlapuu 1, 2*, Joakim Håkansson 3, Lovisa Ringstad 3 and Camilla Björn 2, 3 1 Promore Pharma AB, Karolinska Institutet Science Park, Solna, Sweden, 2 The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at…”
• Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides (2013, background): “Keywords: resistome, transcription, genetic, molecular modeling, antimicrobial peptides, NGS applications”
• A Unified Conformational Selection and Induced Fit Approach to Protein-Peptide Docking (2013, neutral): “Pharmaceutical leads include for example antimicrobial peptides [7,8], cyclic peptides [9] and also”
• Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo (2018, neutral): “Antimicrobial peptide in clinical trials [22,35,118,136].”