Toll-like receptors: key mediators of microbe detection.

By D. Underhill, A. Ozinsky. Current Opinion in Immunology, 2002

754 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/41c59170a8d83b06ed221cf4eefde5c92dda9962

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In Immunology

In Microbiology

Citations in the corpus

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens (2004, background): “Since different cell types express distinct subsets of TLRs, the simultaneous activation of different TLRs creates a unique signal to the cells that is characteristic, both for the cell type and the micro-organism involved [5, 14 ].”
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors (2002, background): “Understanding the functional differences between individual TLRs, especially in terms of signalling pathways and cellular responses induced by various microbial ligands, is a subject of great interes”
Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments (2005, background): “recognized as soluble molecules, and as such cannot be shielded from recognition (Underhill and Ozinsky, 2002; Takeda et al, 2003).”
Host-microbe interactions: shaping the evolution of the plant immune response. (2006, neutral): “Flagellin is recognized as a PAMP by many plant species (Felix et al., 1999) as well as by mammalian innate immunity receptors (Underhill and Ozinsky, 2002).”
Immunotherapeutic uses of CpG oligodeoxynucleotides (2004, background): “The recognition of PAMPs is mediated by members of the Toll-like family of receptors (TLRs”
Mechanisms of Bone Resorption in Periodontitis (2015, background): “Examples of PAMPs that are recognized by TLRs include peptidoglycan bacterial lipoproteins and Pg LPS (TLR-2), double stranded ribonucleic acid, LPS and heat shock proteins (TLR-4), and flagellin (TLR-5) [57, 74].”
Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. (2006, background): “albicans activates specific responses (14, 15), and we and others proposed that this was a universal mechanism of modulation of the innate host defense (13, 41).”
Innate immunity in plants and animals: striking similarities and obvious differences (2004, background): “Nitric oxide is an essential factor for the activation of innate immune responses in humans as well as in insects (5).”