Endothelial Dysfunction: A Marker of Atherosclerotic Risk

By P. Bonetti, L. Lerman, A. Lerman. Arteriosclerosis, Thrombosis and Vascular Biology, 2003

2,340 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/418fe5600910e639d6c9bb2c0eae7e6f6a97705f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. J. Chiu
2. B. J. Gersh
3. Virend K. Somers

In Surgery

1. B. J. Gersh
2. Shu Chien
3. J. Chiu
4. Børge G. Nordestgaard

Citations in the corpus

• Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “In addition to impairments of endothelium-dependent vasodilation, other pathophysiological consequences of endothelial dysfunction specific to atherosclerosis include the following (43, 213, 330): 1) Abnormal vascular reactivity and vasospasm that may cause ischemia, angina, and myocardial infarctio”
• Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. (2004, methodology): “The presence of endothelial ysfunction in coronary or peripheral vessels constitutes an ndependent predictor of cardiovascular events (2).”
• Endothelial dysfunction - a major mediator of diabetic vascular disease. (2013, background): “endothelial cells are metabolically active with important paracrine, endocrine and autocrine functions, indispensable for the maintenance of vascular homeostasis under physiological conditions [1,2].”
• Endothelial Dysfunction and Hypertension. (2016, background): “8) may be due to the elevation in oxidative stress (González et al. 2014; Bonetti et al. 2003).”
• Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “The endothelium represents not only a physical barrier between circulating blood and the underlying tissue but also an important cellular system with autocrine, paracrine and endocrine functions that are highly relevant to vascular homeostasis [236-238].”
• Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome (2005, neutral): “This results in a chronic inflammatory process accompanied by a loss of antithrombotic factors and an increase in vasoconstrictor and prothrombotic products, in addition to abnormal vasoreactivity, therefore elevating risk of cardiovascular events (Bonetti et al 2003) (Figure 1).”
• A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins (2015, neutral): “A prevalent theory states that LDL initiates atherosclerotic plaques when it penetrates through dysfunctional endothelium into the walls of arteries (Bonetti et al., 2003).”