Adaptive immunity maintains occult cancer in an equilibrium state
By Catherine M. Koebel, W. Vermi, J. Swann, Nadeen Zerafa, S. Rodig, Lloyd J. Old, M. Smyth, Robert Schreiber. Nature, 2007
1,413 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/41590083788b7cd293953d930ebf4dff61772ba6
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Citations in the corpus
- CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “Schreiber and colleagues demonstrated that CD4 T cell deficiency in methylcholanthrene-initiated sarcomas enhanced tumor development (Koebel et al., 2007).”
- New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape (2014, positive): “A landmark study in 2007 demonstrated the role of adaptive Th1-like immunity in immune-mediated dormancy of fibrosarcoma [29].”
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors (2009, background): “Notably, the IL-1β–dependent efficacy of doxorubicin could also be shown in a proportion (8 of 15) of primary fibrosarcomas elicited by MCA treatment in vivo”
- Perioperative Clinical Interventions That Modify the Immune Response in Cancer Patients (2013, background): “Thus, it is important to highlight the concept perioperative immunosuppression because it is the time in which dormant [8] and occult tumours [9] and circulating tumour cells [10] have increased possibilities of seed and growing even after the primary tumour has been resected [11].”
- Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses (2012, background): “Cancer Res; 73(3) February 1, 2013 Cancer Research 1130”
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses (2009, positive): “In contrast, a number of recent studies in Rag -knockout mice and mice deficient in interferon signaling show a clear role for lymphocytes in inhibiting cancer development and forcing emerging tumors to edit themselves to evade immune eliminatio”
- Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. (2009, background): “35 (2) Forced expression of IL-17 ectopically in tumor cells can suppress tumor progression through enhanced antitumor immunity in immunecompetent mice.”
- Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation (2021, background): “Highly immunodeficient mice, which completely lack adaptive immunity, develop high rates of spontaneous and carcinogen-induced cancers (1, 2).”