Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments.

By Ilona Kryczek, M. Banerjee, P. Cheng, Linhua Vatan, Wojciech Szeliga, Shuang Wei, E. Huang, Emily Finlayson, D. Simeone, T. Welling and 4 more. Blood, 2009

810 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/3d334eab38e4dda694cfd0a3f7bcd26883760bb2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Lieping Chen
2. Xue Han
3. J. Wolchok
4. W. Zou
5. Jaehyup Kim
6. Christopher Sander
7. Timothy A. Chan
8. Ming O. Li

In Oncology

1. Xue Han
2. Lieping Chen
3. W. Zou
4. J. Wolchok
5. Christopher Sander
6. Timothy A. Chan
7. Ming O. Li
8. D. Pardoll

Citations in the corpus

• Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures (2016, result): “6b) consistent with previous reports [18, 41, 52–55].”
• Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages (2009, methodology): “For detection of cytokine expression inside the macrophages, per respective protocols [23-25], cells were stimulated with LPS 1μg/mL for 24 hours (for IL-10); LPS 1μg/mL for 5 hours (for IL-6); IFN-γ 2000 IU/mL for 2 hours then 1μg/ml LPS for 24 hours (for IL-12); and 1μg/ml Ionomycin with 50nM PMA ”
• PD-L1 (B7-H1) and PD-1 Pathway Blockade for Cancer Therapy: Mechanisms, Response Biomarkers and Combinations (2016, background): “This is in line with the antitumor role of polyfunctional TH17 cells in humanovarian cancer (11, 92).”
• CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, positive): “CD4 + T cells and CD14 + monocytes produced the proinflammatory cytokine IL-18 and IFN-γ –induced chemokines CXCL9 , CXCL10 , and CXCL11 , while IFNG itself originated principally from the remaining CD45 + cells (presumably CD8 + T cells; Figure 8 showing a high correlation among CD8 , CD3 , and IFN”
• Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. (2015, positive): “Additionally, the presence of Th17 cells was shown to correlate with a good prognosis for ovarian cancer (85, 86).”