Stress granules: sites of mRNA triage that regulate mRNA stability and translatability.

By N. Kedersha, Paul Anderson. Biochemical Society Transactions, 2002

796 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4118419bf78c666121bc2537ff8c6e52bfaedd23

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Citations in the corpus

Stress granule assembly is mediated by prion-like aggregation of TIA-1. (2004, background): “It is interesting to note that HSP70 mRNA is excluded from SGs during heat shock (Kedersha and Anderson, 2002), conditions when its translation is permitted while that of most housekeeping mRNAs is prevented.”
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling (2005, background): “We have proposed that SGs are sites of mRNA triage in which individual transcripts are sorted for storage, reinitiation, or degradation (Anderson and Kedersha, 2002; Kedersha and Anderson, 2002).”
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue (2010, neutral): “stressful conditions, cells were exposed to arsenite, an agent is classically used to induce SGs [16,17,18].”
AU-rich elements and associated factors: are there unifying principles? (2006, background): “Stress granules, that accumulate in response to particular physiological signals sequester untranslated mRNAs [reviewed in (119)] but they do not contain decapping factors (112).”
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015, positive): “RNA Facilitates Liquid-Liquid Phase Separation by hnRNPA1 by Binding to RRMs and LCD Stress granules are enriched in RNA-binding proteins and translationally stalled mRNAs (Kedersha and Anderson, 2002).”
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules (2018, background): “The formation of SGs occurs concurrently with alterations in global RNA metabolism, primarily a near-complete shutdown in translation through sequestration of untranslated mRNAs within stalled translation initiation complexes (Kedersha and Anderson, 2002).”
Cytoplasmic foci are sites of mRNA decay in human cells (2004, background): “Stress granules are cytoplasmic structures present in human cells that are related to RNA metabolism and that are induced upon oxidative stress (e.g., treatment with arsenite; Kedersha and Anderson, 2002).”
Stress granules: the Tao of RNA triage. (2008, background): “Endogenous cellular mRNAs encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH), b-actin, c-MYC, insulin-like growth factor II (IGF-II) and H19 are quantitatively recruited to SGs [41], whereas mRNAs encoding heat-shock protein 70 (HSP70) [ 56 ] and heat-shock protein 90 (HSP90) [41] are largely”
Eukaryotic stress granules: the ins and outs of translation. (2009, background): “…of translation initiation complexes by increasing the local concentration of mRNAs and translation factors, though translation itself is unlikely to occur in stress granules, given the absence of 60S subunits, and mRNA species which are translated during stress (Kedersha and Anderson, 2002).”
The Coronavirus Nucleocapsid Is a Multifunctional Protein (2014, background): “The sequestration of N protein in SGs possibly indicates a role in translational suppression.”
The stress granule transcriptome reveals principles of mRNA accumulation in stress granules (2017, positive): “This is consistent with prior models that mRNAs engaged with ribosomes are restricted from entering SGs and provides additional evidence that mRNAs need to be nontranslating to accumulate within SG (Kedersha et al., 2000) (Kedersha and Anderson, 2002).”