Stress granules: the Tao of RNA triage.

By Paul Anderson, N. Kedersha. TIBS -Trends in Biochemical Sciences. Regular ed, 2008

1,136 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9f6cff06010b1f6bda5525628f5c74f24e8e56f1

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In Molecular Biology

Citations in the corpus

Stress granules as crucibles of ALS pathogenesis (2013, background): “The localization, modification, and decay of mRNAs in RNP granules play a critical role in the cellular stress response (Anderson and Kedersha, 2008).”
G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits (2016, methodology): “Their formation is regulated by two related parameters: (a) SG-nucleating proteins, aggregating in response to overexpression (Gilks et al., 2004; Anderson and Kedersha, 2008), de-naturing stresses (heat shock), or molecular crowding (osmotic stress), independent of phospho-eIF2 α (p-eIF2 α ;…”
Angiogenin cleaves tRNA and promotes stress-induced translational repression (2009, background): “Stress-induced translational arrest of mRNAs encoding “housekeeping” proteins is triggered by a family of eIF2 kinases that reduce the availability of eIF2–GTP–tRNAi ternary complexes required for translation initiation (Anderson and Kedersha, 2008).”
Inhibition of PKR by Viruses (2021, background): “Translation blockade results in the rapid formation of stress granules (SGs; Anderson and Kedersha, 2008; McCormick and Khaperskyy, 2017).”
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue (2010, background): “Co-localization with PABP is considered a strong indication of coincident localization of mRNA.”
MicroRNA Functions in Stress Responses (2010, positive): “The formation of these granules can be triggered by the phosphorylation of eIF2a, which is governed by five stress-sensing kinases (Anderson and Kedersha, 2008): (1) PKR responds to viral infection, heat, and UV irradiation; (2) PERK senses ER stress; (3) GCN2 is activated by amino acid deprivation;”
MicroRNA and cancer (2012, background): “Stress granules are intracellular proteinRNA aggregates that can form under stress conditions and they are proposed to regulate mRNA metabolism and act as storage centres for translationally repressed mRNAs (Anderson and Kedersha, 2008).”
ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐mediated nuclear import (2010, background): “Hence, it seems possible that in the presence of chronic stress, such as oxidative stress, viral infections or proteasome inhibition (Anderson and Kedersha, 2008), small stress granules give rise to larger granules and eventually to large, insoluble inclusions.”
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules (2020, background): “(P-eIF2 ) represses translation and causes aggregation of stalled translation preinitiation complexes containing mRNAs, initiation factors, small ribosomal subunits, and RNA-binding proteins, together with the Ras-GAP SH3 domain binding protein (G3BP) and T-cell-restricted intracellular antigen 1 (T”
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets (2009, positive): “It is noteworthy that some studies demonstrated the association of P-bodies and stress granules and suggested the possibility of exchange of material between P-bodies and stress granules (Anderson and Kedersha, 2008).”
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, background): “The formation of SG is a reversible process and SGs dissolve after the stress is over (Anderson and Kedersha, 2008).”