The Coronavirus Nucleocapsid Is a Multifunctional Protein

By R. McBride, Mr G Van Zyl, Burtram C. Fielding. Viruses, 2014

864 citations recorded by the source corpus.

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/b190452f13e95ef0af0c07243e44a98371fe00eb

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Citations in the corpus

• The Molecular Docking Study of Potential Drug Candidates Showing Anti-COVID-19 Activity by Exploring of Therapeutic Targets of SARS-CoV-2 (2020, background): “The NTD is known to facilitate RNA binding and the CTD plays an important role in dimerization.[32, 33] The CL region includes several phosphorylation sites, as well as arginine-serine.”