Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution.

By I. Xynos, A. Edgar, L. Buttery, L. Hench, Julia M. Polak. Journal of Biomedical Materials Research, 2001

1,174 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/404b0764d0772fb3568dff28908e90f9afc6e2f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Julian R. Jones
2. Aldo R. Boccaccini
3. K. Rezwan
4. Qizhi Chen
5. Molly M. Stevens
6. J. Blaker
7. A. Tilocca

In Molecular Biology

1. Julian R. Jones
2. Molly M. Stevens
3. Aldo R. Boccaccini

In Rheumatology

1. K. Rezwan
2. Qizhi Chen
3. J. Blaker
4. Aldo R. Boccaccini

Citations in the corpus

• Structural models of bioactive glasses from molecular dynamics simulations (2009, background): “This could be related to the release of specific amounts of Si, P, Na and Ca ions, whose local concentration in the physiological environment can approach critical values needed to stimulate the cellular activity (Xynos et al. 2000, 2001; Hench & Polak 2002; Day 2005; Boccaccini et al. 2007).”
• Review of bioactive glass: from Hench to hybrids. (2013, background): “5-fold up-regulation of apoptosis regulators, the 2- to 5-fold up-regulation of cell cycle regulators and the 2- to 3-fold up-regulation of DNA synthesis [117].”
• Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering (2010, neutral): “For example, it has been demonstrated that dissolution products from bioactive glasses up-regulate the expression of genes that control osteogenesis [7,51], which explains the higher rate of bone formation in comparison to other inorganic ceramics such as hydroxyapatite [52].”
• Silk fibroin as biomaterial for bone tissue engineering. (2016, background): “The enhanced osteoregenerative ability of the bioactive glass/SF scaffolds is mainly attributed to the consistent release of silica from bioactive glasses which subsequently up-regulates the bone-related markers in osteoblasts [162].”
• Complexity in biomaterials for tissue engineering. (2009, background): “Bioactive glasses such as PerioGlas can be made to release various ions including calcium and silicon, which can effect upregulation of genetic pathways relevant to bone differentiatio”
• Silicon substitution in the calcium phosphate bioceramics. (2007, positive): “The dissolution products of Bioglass, which contain high levels of aqueous Si, stimulate osteogenesis and collagen synthesis [23].”