Lead- and drug-like compounds: the rule-of-five revolution.

By Christopher A. Lipinski. Drug Discovery Today : Technologies, 2004

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Medicinal chemical properties of successful central nervous system drugs (2005, background): “As such, medicinal chemists have enthusiastically adopted the Rule of Five.(81) Two studies have contrasted physical chemical properties of CNS-marketed drugs to either non-CNS drugs in general or to other classes of non-CNS drugs.”
The influence of drug-like concepts on decision-making in medicinal chemistry (2007, background): “jpg" NDATA ITEM> ]> Ten years have passed since the publication of the 'rule of five' physical property guidelines for drug permeabilit”
A data-driven approach to predicting successes and failures of clinical trials (2016, result): “…we reasoned that a new approach that includes overlooked features related to the results of a drug’s performance could prove to be highly impactful, similar to the effect that adopting sabermetrics had on the base-ball scouting process as described in Michael Lewis’s Moneyball (Lewis, 2003).”