The influence of drug-like concepts on decision-making in medicinal chemistry

By Paul D. Leeson, B. Springthorpe. Nature reviews. Drug discovery, 2007

2,167 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

A data-driven approach to predicting successes and failures of clinical trials (2016, background): “The adoption of drug-likeness concepts early in the drug discovery process has been shown to reduce attrition rates (Leeson and Springthorpe, 2007).”
Quantifying the chemical beauty of drugs. (2012, background): “It has been shown that the preferential selection of drug-like compounds increases the likelihood of surviving the well-documented high rates of attrition in drug discover”
EASL Clinical Practice Guidelines: Drug-induced liver injury. (2019, background): “Lipophilicity (often measured as the log of octanol-water partition coefficient, LogP) is known to influence various drugrelated aspects such as potency, pharmacokinetics and toxicity.(120,121) Drugs with higher lipophilicity appear to have increased off-target binding as well as an increased likeli”
Ligand–receptor interaction platforms and their applications for drug discovery (2012, background): “Since then, the concept of ligand efficiency has been extended to include several new matrices including binding efficiency index (affinity/molecular weight), percentage efficiency index (% inhibition/molecular weight), surfacebinding efficiency index (affinity/van der Waals polar surface area) [37-”