Medicinal chemical properties of successful central nervous system drugs

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Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity (2023, background): “Removal of the carboxylic acid would promote passive brain permeability and potentially provide a tool suitable for use in exploring Wnt signalling in disease of the CNS [24,25].”
A perspective on multi-target drug discovery and design for complex diseases (2018, background): “These multiple factors increase the complexity of CNS drug discovery [72].”
Microbial bio transformation: a process for chemical alterations (2017, background): “In recent years, interests in the biotransformation of various pollutants using microorganisms have gathered much momentum in order to clean up the polluted environment [27].”