Biochemical and physiological function of stearoyl-CoA desaturase.

By C. Paton, J. Ntambi. American Journal of Physiology. Endocrinology and Metabolism, 2009

713 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Cellular Fatty Acid Metabolism and Cancer (2013, background): “SCD SCD catalyzes the introduction of double bonds into short-chain FAs in the C9 position (mainly converting stearoyl-CoA to oleoylCoA) (Paton and Ntambi, 2009).”
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins (2013, background): “SCD is expressed as multiple isoforms (SCD1,2,3,4 in mice; SCD1,5 in humans), which share >80% sequence identity but are differentially expressed and regulated (Flowers and Ntambi, 2008; Paton and Ntambi, 2009).”
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011, positive): “Lipids are implicated in regulating Scd1 gene transcription (for a review, see Paton and Ntambi, 2009), and elevated hepatic lipids in SIRT3KO mice lead to increased transcriptional signals that further activate Scd1 expression.”
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. (2010, background): “(SCDs), [25] and fatty acid desaturases (FADS) [26].”