Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

By T. Rodgers, David E. Leahy, M. Rowland. Journal of Pharmacy and Science, 2005

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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates. (2009, methodology): “105,106,142) give the ability to separate drug attributes from those of the system and to incorporate times have removed this restriction.”
PBPK models for the prediction of in vivo performance of oral dosage forms. (2014, methodology): “The fractions of lipid, protein, and water in each organ and sub-compartment are embedded in the software, enabling the calculation of tissue–plasma-partition coefficients using five different approaches (PK-Sim standard (PK-Sim , 2012), Rodgers and Rowland (Rodgers et al., 2005a,b; Rodgers and Rowl”
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model (2016, background): “to electrostatic interactions at physiological pH.(45,46) These include binding of ionized and unionized drugs to acidic phospholipids and neutral lipids, respectively.”