Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

By L. Kuepfer, Christoph Niederalt, Thomas Wendl, Jan-Frederik Schlender, S. Willmann, J. Lippert, Michael Block, T. Eissing, Donato Teutonico. CPT: Pharmacometrics & Systems Pharmacology, 2016

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The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.

Subfields: Building and Construction, Geography, Planning and Development, Management Science and Operations Research

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