The role of acetylcholine in learning and memory.

By Michael E. Hasselmo. 2006

1,635 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

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Citations in the corpus

Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment (2023, background): “Treatment with anticholinergic drugs can lead to cognitive impairments in these domains as a side effect, and the majority of medications used for treating symptoms of Alzheimer ’ s disease operate by promoting cholinergic signalling [179, 180].”
Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of NeoHebbian Three-Factor Learning Rules (2018, background): “…1993) and spike-timing dependent plasticity (STDP) (Markram et al., 1997; Zhang et al., 1998; Sjöström et al., 2001) neglect that additional factors such as neuromodulators or other gating signals might be necessary to permit synaptic changes (Gu, 2002; Reynolds and Wickens, 2002; Hasselmo, 2006).”
Efficient Partitioning of Memory Systems and Its Importance for Memory Consolidation (2013, neutral): “Cholinergic tone, in particular, has been shown to selectively modulate hippocampal and some recurrent cortical synapses (see [20]) as well as thalamocortical synapses [21].”
Incremental learning algorithms and applications (2016, background): “Here, learning is conceivably enhanced through acetylcholine release in case of task failures [163, 70].”
Selectionist and Evolutionary Approaches to Brain Function: A Critical Appraisal (2012, background): “It works rather like Hebbian learning. Hebb (1949) said that neurons that fire together wire together, which means that the synapse connecting neuron A to neuron B gets stronger if A and B fire at the same time.”
Hybrid carbon based nanomaterials for electrochemical detection of biomolecules (2017, background): “7 nmol/g, n = 9, hippocampus, in vivo mouse Acetylcholine Plays a role in encoding new memories Y – [265,287,288] 16.”
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development (2007, background): “Alzheimer's disease and cognitive impairments A convincing body of data indicate that mAChRs have central roles in facilitating cognitive function”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (neutral): “Although over the past few decades the role of neuromodulation in certain forms of synaptic plasticity that mainly used high frequency stimulation induction protocols has been well established, it is not clear how these results relate to STDP (for reviews see: Jay, 2003; Hasselmo, 2006; Sara, 2009; ”
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis (2011, background): “In such a case, interference may appear in other layers, such as the CA3, but that may be solved by an encoding mechanism separate from neurogenesis (Hasselmo, 2006; Leutgeb et al. , 2007; Myers & Scharfman, 2009).”
Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules (2016, background): “…plasticity, and behavioral learning has been reviewed before (Martin et al., 2000; Gu, 2002; Reynolds and Wickens, 2002; Schultz, 2002, 2006; Hasselmo, 2006; Shohamy and Adcock, 2010; Lisman et al., 2011; Nadim and Bucher, 2014), this review mainly focuses on the case of STDP under the…”
A Bio-Inspired Incremental Learning Architecture for Applied Perceptual Problems (2016, background): “Learning is conceivably enhanced through acetylcholine release in case of task failures [15, 16], leading to higher ”prototype density” in difficult regions of the sensory space.”
Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition (2010, methodology): “Cellular data on the effects of ACh in cortical structures guide the development of circuit-level models of the behavioral role of ACh (Hasselmo, 2006; Hasselmo and Stern, 2006).”