Histone methyltransferase activity of a Drosophila Polycomb group repressor complex.

By Jürg Müller, C. M. Hart, N. Francis, M. Vargas, Aditya K. Sengupta, B. Wild, Ellen L. Miller, M. O’Connor, Robert E. Kingston, J. Simon. Cell, 2002

1,641 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3f82e7743d5b788850d488c680142c36a5f9f6be

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Control of developmental regulators by Polycomb in human embryonic stem cells. (2006, background): “PRC2 catalyzes histone H3 lysine-27 (H3K27) methylation, and this enzymatic activity is required for PRC2-mediated gene silencing (Cao et al., 2002; Czermin et al., 2002; Kuzmichev et al., 2002; Muller et al., 2002; Kirmizis et al., 2004).”
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. (2007, background): “PRCs contain intrinsic histone methyltransferase (HMTase) activity and maintain gene repression through methylation of core histones (Beisel et al. 2002; Cao et al. 2002; Milne et al. 2002; Muller et al. 2002; Nakamura et al. 2002).”
Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “In mammals, the catalytic core of PRC2 is comprised of EZH1 or EZH2, which trimethylate histone H3 on lysine 27 (H3K27me3) (Cao et al., 2002; Czermin et al., 2002; Kuzmichev et al., 2002; Müller et al., 2002).”
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity (2004, background): “We and others have identified SUZ12 as a target of the E2F transcription factors (Muller et al, 2001; Weinmann et al, 2001; Bracken et al, 2003).”
Histone methylation by PRC2 is inhibited by active chromatin marks. (2011, background): “Among the PcG protein complexes, Polycomb repressive complex 2 (PRC2) is a histone methyl-transferase (HMTase) that methylates Lys27 of H3 (H3K27) (Cao et al., 2002; Czermin et al., 2002; Kuzmichev et al., 2004; Müller et al., 2002).”