Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

By A. Seiler, Manuela Schneider, H. Förster, Stephan Roth, E. Wirth, C. Culmsee, N. Plesnila, E. Kremmer, O. Rådmark, W. Wurst and 3 more. Cell Metabolism, 2008

1,354 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/3f7531ee892d481202916821beeaa069533cb030

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

In Physiology

Citations in the corpus

The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, neutral): “GSH depletion also results in the activation of 12/15 lipoxygenase (12/15LOX) (144) most probably because of the resulting inhibition of GSH peroxidase 4 (GPx4) (242), which depends on an adequate supply of GSH for activity.”
Neuronal Cell Death. (2018, neutral): “Ferroptosis appears to require the iron-dependent lipid peroxidation of polyunsaturated fatty acids, and although the mechanisms that result in necrosis downstream of lipid peroxidation remain unclear, they may involve AIF release from mitochondria and nuclear translocation (530, 613, 761).”
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. (2017, positive): “(F) PFa1 cells (Seiler et al., 2008) expressing doxycycline (Dox) dependent exogenous wildtype and GPX4-Cys were treated with different doxycycline concentrations.”
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. (2017, neutral): “Enzymatic effectors, such as non-heme, iron-containing proteins, including lipoxygenases (LOXs), can mediate ferroptotic peroxidation (Kagan et al., 2017; Seiler et al., 2008; Yang et al., 2016).”
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. (2022, neutral): “, 2011), as well as from the finding by Marcus Conrad and colleagues in 2008 that the genetic modulation of key genes controlling redox state drove non-apoptotic cell death (Banjac et al., 2008; Seiler et al., 2008).”
Ferroptosis: mechanisms and links with diseases (2021, background): “Most of the oxytosis studies have been carried out in HT22 cells that were explicitly sensitive to glutamate toxicity.(91) The defective GPx4 expression can enhance cytotoxicity by glutamate-induced oxytosis in the retina.”
Regulation of Ferroptotic Cancer Cell Death by GPX4 (2014, background): “conditional Gpx4 knockout mice and analyzed the cell death mechanisms after Gpx4 inhibition (Seiler et al., 2008; Sengupta et al., 2013; Ueta et al., 2012; Yoo et al., 2012).”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “[223,255]—gain and loss of GPX activity is sufficient to disable and activate ferroptosis [256], respectively.”