Regulation of PDGF and its receptors in fibrotic diseases.

By J. Bonner. Cytokine & growth factor reviews, 2004

776 citations recorded by the source corpus.

Subfields: Pulmonary and Respiratory Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/3ef4ee7d8e6ac2a4b4459d18085cbf7550ee8285

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In Pulmonary and Respiratory Medicine

In Rheumatology

Citations in the corpus

Macrophages: Master Regulators of Inflammation and Fibrosis (2010, background): “One is PDGF, which stimulates the proliferation, survival, and migration of myofibroblasts.(62,63) Imatinib mesylate (STI-571, Gleevec), a PDGF receptor tyrosine kinase inhibitor, is accordingly in preclinical development as a possible therapy for chronic hepatic fibrosis.”
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets (2006, background): “Albeit much effort has been made to study the effects of PDGF-BB and TGF-β on HSC, their interaction is still unclear, but it is most likely that both cytokines have differential and synergistic effects in the course of fibrogenesis.”
Pathogenetic mechanisms in radiation fibrosis. (2010, background): “In the lung, dermis and heart, PDGF signal is produced by activated mesenchymal cells (fibroblasts, mesangial cells and stellate cells), macrophages and inflammatory cells [53].”
Role of platelet-derived growth factors in physiology and medicine. (2008, neutral): “However, inflammatory cytokines such as IFN- , IL-1 , and IL-13 have been implicated (Bonner 2004).”
Therapy for Fibrotic Diseases: Nearing the Starting Line (2013, background): “In response to these and other growth factors, the cellular precursors of myofibroblasts (pericytes, resident fibroblasts, hepatic stellate cells, and renal mesangial cells) (Table 1) also up-regulate their expression of PDGF receptor b (PDGFRb) (38), one of many positive feedback loops that can dri”
Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs (2013, neutral): “PDGFR β (platelet derived growth factor receptor beta) induction is an early feature of myofibroblast activation in a broad range of tissues 17,18,19,20,21,22,23,24 .”
Aberrant repair and fibrosis development in skeletal muscle (2011, background): “In vitro, PDGF production can be induced by TGFb, which also stimulates fibroblasts to contract collagen matrices and differentiate into myofibroblasts [88].”