Therapy for Fibrotic Diseases: Nearing the Starting Line
By S. Friedman, D. Sheppard, Jeremy S. Duffield, S. Violette. Science Translational Medicine, 2013
667 citations recorded by the source corpus.
Subfields: Pathology and Forensic Medicine, Physiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/9265aa0e7c8bc0e38358dffcf4856375c42e2330
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In Pathology and Forensic Medicine
In Physiology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Hepatic stellate cells as key target in liver fibrosis (2017, background): “its receptors, or blocking its activation at the cell surface, have been challenging due to adverse effects of systemic TGFβ antagonism, including inflammation and cancer [6,7,114].”
- TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “Commonly affecting many organs includinglung, heart, kidney, and liver, tissue fibrosis is a leading cause of morbidity and mortality worldwide (Friedman et al. 2013).”
- Wound repair and regeneration: Mechanisms, signaling, and translation (2014, neutral): “…appear to exist, there is increasing appreciation of common pathways of fibrosis that are conserved among tissues, including transforming growth factor– β (TGF β ), connective tissue growth factor (CTGF), interleukin-4 (IL-4), IL-13, platelet-derived growth factor (PDGF), and osteopontin (19).”
- Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “Fibrosis is estimated to contribute to almost 50% of all deaths in the developed world (Friedman et al., 2013), and despite the existence of drugs that can delay its progression, to date there is no truly curative treatment (Dempsey et al.”
- Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “The term fibrosis, however, refers to a pathological and excessive tissue scarring which takes place during reactive responses to recurrent and persistent tissue injuries (77).”
- Cellular and molecular mechanisms in kidney fibrosis. (2014, positive): “Conclusions Although controversies remain as to the origins of kidney myofibroblasts, there is an evolving consensus that FOXD1-lineage cells are the major precursor population of pathological fibrillar matrix-forming cells in kidney disease (19, 22, 30, 101, 102).”