T-helper-1-cell cytokines drive cancer into senescence
By H. Braumüller, T. Wieder, E. Brenner, Sonja Assmann, M. Hahn, M. Alkhaled, K. Schilbach, F. Essmann, M. Kneilling, C. Griessinger and 20 more. Nature, 2013
683 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/3ecfae8856c499e9ff60645fa01bec5a738155a1
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Citations in the corpus
- Immunosenescence: molecular mechanisms and diseases (2023, background): “Mitochondrial metabolic disorders cause a type 1 cytokine inflammatory storm of TNF-α and IFN-γ, subsequently inducing inflammaging in peripheral tissues.(2,165) Conceivably, sustained secretion of the SASP factor in tissues is a significant source of inflammaging (Fig.”
- CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy (2019, background): “IFN γ and tumor necrosis factor alpha (TNF α ) are two major cytokines released by effector CD8 + T cells 4,13 .”
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence (2017, neutral): “The induced expression of ISGs along with the reported role of type I IFNs in senescence, prompted us to examine whether cGAS-mediated secretion of type I IFNs is involved in promoting oxidative stress-induced senescence 39, 40, 41, 42.”
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses (2015, background): “Multiple types of immune cells are involved in tumor immunosurveillance and of particular importance are the tumor-infiltrating lymphocytes (TILs) (i.e., T cells) (Braumüller et al., 2013; Shiao et al., 2011).”
- Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Moreover, increasing evidence shows that the microbiota is important for the efficacy of both classical chemotherapy (328) and of immune checkpoint inhibitors (anti–PD-L1, anti–CTLA-4, and anti-PD1) (298, 327).”
- CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, neutral): “Tumor-associated Th1 cytokines, lead by IFN-γ , have consistently been linked with more potent antitumor immune responses in a variety of solid tumors (59, 60), with recent research showing that tumor-specific Th1 cells can effectively control tumor development (61, 62).”
- Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. (2016, background): “In multiple murine models and in human cancers, T helper 1 cell production of IFN-γ and TNF-α induce immune-dependent tumor cell senescence (45).”