Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.

By S. Bruno, Cristina Grange, M. Deregibus, R. Calogero, S. Saviozzi, F. Collino, L. Morando, A. Busca, M. Falda, B. Bussolati and 2 more. Journal of the American Society of Nephrology, 2009

1,235 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3ec1cf38290f9dd601482fd3ffc1405adf827b93

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Citations in the corpus

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “Such models of disease include a myocardial I/R model in which MSC exosomes decreased infarct size and ameliorated reperfusion injury (24); a cisplatin-induced acute kidney injury model in the rat in which adipose tissue MSC exosomes ameliorated oxidative stress and cell apoptosis, promoting cell pr”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “In addition, exosomal transfer from MSCs is reported to reduce inflammation and to increase cell proliferation during tissue repair [162, 165, 166].”
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, background): “By exerting anti-apoptotic activities, human MSC-EVs were as effective as their parental cells in promoting kidney regeneration in severe combined immunodeficiency (SCID) mice with glycerolinduced acute kidney injury (103).”
Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. (2011, methodology): “In this model, MVs induced epigenetic changes in resident cells by delivering their messenger RNA (mRNA) cargo leading to reentry into the cell cycle and activation of tissue regenerative programmes [23].”
Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model (2013, background): “It has been proven that EVs can be released by various stem cells and progenitors [11, 12] including MSCs [13, 14].”
Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs (2010, methodology): “mTEC were isolated, cultured and characterized as previously described [8].”
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (2013, background): “Exosomes have been shown to reducemyocardial ischemia/reperfusion injury [32] or acute tubular injury [33].”
Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases (2019, background): “[70] and Ju and et al [73], MSC-EV-based renoprotection was diminished by RNase pretreatment [74], confirming the hypothesis that beneficial effects of MSCs-EVs were mainly mediated by MSC-sourced mRNA.”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “Treatment of mice with these EVs protected against glycerol or cisplatin-induced kidney injury (187,188).”
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. (2014, background): “The paracrine capacity of MSCs appears to be an important mechanism in determining their efficacy when used for regenerative therapies [14].”
Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “[21] tested the effect of human bone marrow MSC-EVs in glycerol-induced AKI in SCID mice.”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Human umbilical cord MSC-derived EVs protect against acute renal injury and liver fibrosis [273,274].”