CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

By Y. Fukata, T. Itoh, Toshihide Kimura, Céline Ménager, Takashi Nishimura, Takashi Shiromizu, Hiroyasu Watanabe, N. Inagaki, A. Iwamatsu, H. Hotani and 1 more. Nature Cell Biology, 2002

762 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/3e1141d8d78bd55ee41deca67e172e0d98457045

How researchers see this paper

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In Cell Biology

1. Cecilia Conde
2. A. Cáceres
3. A. Ridley
4. Alan Hall
5. A. Jaffe
6. Kozo Kaibuchi
7. E. Dent
8. S. Newey

In Cellular and Molecular Neuroscience

1. Cecilia Conde
2. A. Cáceres
3. Kozo Kaibuchi
4. E. Dent
5. F. Gertler

Citations in the corpus

• Microtubule assembly, organization and dynamics in axons and dendrites (2009, background): “, where it promotes the assembly of tubulin subunits onto the ends of existing microtubules and is required for axon formatio”
• Rho GTPases: biochemistry and biology. (2005, background): “Expression of constitutively active Rac or Cdc42 enhances the ability of CLIP170 to bind to IQGAP, thereby promoting plus end capture (M. Fukata et al. 2002).”
• Neuronal polarity: from extracellular signals to intracellular mechanisms (2007, background): “CRMP2 interacts with tubulin heterodimers and promotes microtubule assembly in vitro”
• The role of the Rho GTPases in neuronal development. (2005, background): “CRMP-2 is capable of binding tubulin heterodimers and promoting microtubule assembly, and, importantly, a CRMP-2 mutant unable to promote microtubule assembly inhibits axonal growth and branching (Fukata et al. 2002).”
• ROCKs: multifunctional kinases in cell behaviour (2003, background): “It seems that CRMP2 normally promotes axon outgrowth, possibly through its ability to promote microtubule assembl”
• Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. (2006, background): “CRMP-2 also regulates microtubule assembly and polymerization (Fukata et al., 2002).”
• Cytoskeletal dynamics and transport in growth cone motility and axon guidance. (2003, background): “Phosphorylation regulates the microtubule-desta- and CLIP-170.”