Interleukin 1 in the brain: biology, pathology and therapeutic target.

By N. Rothwell, G. Luheshi. Trends in Neurosciences, 2000

699 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/3d8fa85e6d0baecd8d7bf8692105cd6cb6f43ef2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Rivest
2. Neil A. Harrison
3. Hugo D. Critchley

In Neurology

1. S. Rivest
2. Hugo D. Critchley
3. Neil A. Harrison

Citations in the corpus

• The role of inflammation in CNS injury and disease (2006, background): “IL-1 was discovered as an important endogenous pyrogen, and is now recognised as the ‘prototypic inflammatory cytokine’ (reviewed by Rothwell & Luheshi, 2000).”
• The inflammatory response in stroke. (2007, background): “IL-1 has two receptors, IL-1R1 and IL-1R2, but only the former is involved in signal transduction (Rothwell and Luheshi, 2000).”
• IL‐1, IL‐18, and IL‐33 families of cytokines (2008, background): “Diseases of the central nervous system An extensive literature exists on the production of IL-1b by microglial and other cells in the brain, primarily in the hypothalamus (50, 51).”
• Research and treatment approaches to depression (2001, background): “The biology of specific brain cytokines has been the topic of recent review”
• Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults (2008, background): “…and IL-1β upregulate adhesion molecules, increase leukocyte migration across the CNS endothelial cells, and regulate BBB permeability (Hickey 2001; Rothwell and Luheshi 2000), whereas TNFα and IL-6 disrupt the BBB through the release of endothelial nitric oxide or, in the case of a transgenic…”
• Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke (2009, background): “To clarify the attenuating effect of T reg cells on early postischemic proinflammatory cytokine production, we focused on microglia, the main source of cerebral TNF-α and IL-1β productio”