Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA

By Rong-guang Zhang, K. Pappas, J. Brace, P. Miller, Tim N. Oulmassov, John M. Molyneaux, John C. Anderson, J. Bashkin, S. C. Winans, A. Joachimiak. Nature, 2002

437 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3d7994ca8fc635b662314a091e295b6df60b2a72

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In Ecology

1. S. Rutherford
2. B. Bassler

In Genetics

1. S. Rutherford
2. B. Bassler
3. Wai‐Leung Ng
4. Paul Williams
5. Emeran A. Mayer
6. Brian K. Hammer

In Molecular Biology

1. S. Rutherford
2. Wai‐Leung Ng
3. B. Bassler
4. Paul Williams
5. V. Sperandio
6. Brian K. Hammer
7. Emeran A. Mayer

Citations in the corpus

• Exploiting Quorum Sensing To Confuse Bacterial Pathogens (2013, background): “For other AHL receptors, including TraR and LasR, the native ligands are postulated to trigger a protein folding switch that is required for proper folding of the receptor, which enhances protein stability (175–179).”
• Bacterial quorum sensing: its role in virulence and possibilities for its control. (2012, background): “Structures of other LuxR-type QS regulators, TraR, SdiR, and CviR, have also been solved enabling comparative analysis (Vannini et al. 2002; Zhang et al. 2002; Yao et al. 2006; Chen et al. 2011).”
• Inter-kingdom signalling: communication between bacteria and their hosts (2008, background): “The three-dimensional structure of TraR indicated that if bound to its ligand ( N -(3-oxo-octanoyl)- L -homoserine lactone) it shared structural similarities with the evolutionarily conserved PAS and GAF domain”
• Quorum sensing, communication and cross-kingdom signalling in the bacterial world. (2007, background): “For both TraR and LasR, models have been proposed in which AHL binding to the nascent protein facilitates protein folding and dimerization , enabling DNA binding and transcriptional activation of the target QS genes (Zhang et al., 2002; Bottomley et al., 2007).”
• Bacterial Quorum-Sensing Network Architectures (2009, positive): “Supporting this notion is the finding that the crystal structure of the 3OC8HSL-TraR complex reveals that the ligand is completely buried within the protein (127, 145).”
• Dimerization allows DNA target site recognition by the NarL response regulator (2002, background): “, and has now been found in prokaryotic transcription factors, such as Tra”