Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.

By C. Poland, R. Duffin, I. Kinloch, Andrew D. Maynard, W. Wallace, A. Seaton, Vicki Stone, Simon B. Brown, W. Macnee, Ken Donaldson. Nature Nanotechnology, 2008

2,591 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/3d651f1a123a46dcf6bc0007f5150fecacbf6707

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In Health, Toxicology and Mutagenesis

In Materials Chemistry

Citations in the corpus

Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. (2009, background): “The clinical relevance of carbon nanotubes, however, has been under debate because of concerns over their toxicity, although there are differences in opinions among investigator”
Biodegradable luminescent porous silicon nanoparticles for in vivo applications (2009, background): “or the toxic structural characteristics of the nanomaterials themselve”
Evaluating the Control Banding Nanotool: a qualitative risk assessment method for controlling nanoparticle exposures (2009, background): “A recent Dutch NRC article refers to the similarity between carbon nanotubes and asbestos, both in their dimensions as well as their pathogenicity (Poland et al. 2008), and a recent San Francisco D. M. Zalk (&) S. Y. Paik Lawrence Livermore National Laboratory, P.O. Box 808, L-871, Livermore, CA…”
Toxicity assessment of nanomaterials: methods and challenges (2010, background): “In vivo studies: pulmonary toxicity, asbestos-like, length-dependent, pathogenic behavior; induce inflammation, formation of granuloma, cytotoxicity and rapid development of fibrosis in lungs; apoptosis of alveolar macrophages [87–92]”
Techniques for physicochemical characterization of nanomaterials (2013, background): “Furthermore, recent studies demonstrated an asbestos-like pathogenic responsewhen carbonnanotubes of length greater than 20 μm were delivered into the abdominal cavity of mice (Kostarelos, 2008; Poland et al., 2008; Powers et al., 2009; Takagi et al., 2008).”
Flexible, Stretchable Sensors for Wearable Health Monitoring: Sensing Mechanisms, Materials, Fabrication Strategies and Features (2018, background): “For example, it has been reported that injecting large quantities of CNTs into mice lungs could cause asbestos-like pathogenicity because of the small size and needle-like morphology of CNT [206].”
Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. (2009, background): “There is evidence based on some toxicological studies that prolonged accumulation of long (>10 μm), rigid, pristine nanotubes in tissues may be associated with health risks such as carcinogenesis and should be avoide”
Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, neutral): “and observing carcinogenic mechanisms in the abdominal cavity and on the diaphragm [61].”
Magnetic nanoparticles: essential factors for sustainable environmental applications. (2013, background): “However, some studies found that carbon nanotubes cause injury in mice during inhalation exposure (Lam et al., 2004; Poland et al., 2008).”