The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

By G. Clarke, S. Grenham, P. Scully, P. Fitzgerald, R. Moloney, F. Shanahan, Ted G. Dinan, J. Cryan. Molecular Psychiatry, 2013

1,739 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/3d5abab291fdc8449b25d82de7556be2c1d8b088

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. J. Foster
5. L. Rinaman
6. P. Kennedy
7. C. Stanton
8. S. Mazmanian

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. Yan Wang
7. L. Kasper
8. T. Sampson

In Social Psychology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. T. Sampson
6. R. Stilling
7. C. Stanton
8. Yan Wang

Citations in the corpus

• Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease (2016, positive): “, 2015) and affects anxiety, hyperactivity, and cognition (Clarke et al., 2013; Diaz Heijtz et al., 2011; Neufeld et al., 2011; Selkrig et al., 2014).”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “…6 October 2015 | Volume 9 | Article 392 also suggests that the serotonergic system may be under the influence of gut microbiota, especially, but not limited to, periods prior to the emergence of a stable adult-like gut microbiota (Desbonnet et al., 2008; El Aidy et al., 2012; Clarke et al., 2013).”
• Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “We have shown that germ-free mice have a marked increase in 5-HT concentrations in the hippocampus (Clarke et al. 2013), whereas Neufeld and colleagues have shown a decreased 5-HT1A receptor gene expression in the hippocampal dentate gyrus of female germ-free animals using in situ hybridisation (Neu”
• Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. (2016, background): “, 2004), altered tryptophan metabolism (Clarke et al., 2013; El Aidy et al., 2012; O'Mahony et al., 2015; Yano et al., 2015), neurotrophic factors (Bercik et al.”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “system which could explain the reduced kynurenine pathway metabolism in these animals (see below) (Clarke et al., 2013).”
• The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology (2020, background): “The importance of tryptophan metabolism in maintaining CNS homeostasis was already known a few years earlier, since male GF animals have significantly higher levels of 5-hydroxytryptamine and 5hydroxyindoleacetic acid in the hippocampus and the serum, compared with conventionally colonized control a”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, positive): “…Genes, Brain and Behavior (2014) 13: 69–86 T ab le 2: B io ch em ic al an d m ol ec ul ar al te ra tio ns w ith di ff er en tia lm ic ro bi ot a co m po si tio n Genes, Brain and Behavior (2014) 13: 69–86 73 a critical time window during adolescence (Clarke et al. 2013; Foster & Neufeld 2013).”