An obesity-associated gut microbiome with increased capacity for energy harvest

By Peter J. Turnbaugh, Ruth E. Ley, M. Mahowald, Vincent J. Magrini, Elaine R. Mardis, Jeffrey I. Gordon. Nature, 2006

11,838 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/3d1017e9ba7835ee50ed4587248b3b9e0f7533bb

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Citations in the corpus

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015, positive): “In particular the decreased SCFAs levels in RYGB and VBG fecal samples also point to reduced energy harvest from the diet, as previously proposed (Turnbaugh et al., 2006).”
The human gut microbiota: Metabolism and perspective in obesity (2018, background): “Methane-producing archaea (methanogens) have been shown to affect caloric harvest by increasing the capacity of polysaccharide-eating bacteria to digest polyfructose containing glycans, which leads to increased weight gain in mice.(41) A study demonstrated that humans with methane detectable via a b”
Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations (2018, background): “This is perhaps not surprising, as increased body weight in obesity is associated with increased SCFA levels (Turnbaugh et al. 2006; Schwiertz et al. 2010; Fernandes et al. 2014; Rahat-Rozenbloom et al. 2014), as well as increased colonic FFAR2 and FFAR3 gene expression (Lu et al. 2016).”
Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population (2017, background): “A possible explanation for our findings is that Firmicutes are more effective as an energy source than Bacteroidetes, thus promoting more efficient absorption of calories and subsequent weight gain [5, 6].”
The role of the gut microbiota in energy metabolism and metabolic disease. (2009, background): “They found that after only two weeks, mice harbouring the microbiota from obese mice had a modest fat gain, and extracted more calories from their food compared to the lean mice having received the gut microbiota from lean mouse donors [13].”
The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “The same trend is observed within individual humans on weight-reduction diets (reviewed in Ley, 2010), although a study with human twins showed that in obese individuals, the decrease in Bacteroidetes was accompanied by an increase in Actinobacterium rather than in Firmicutes (Turnbaugh et al., 2009”
Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development (2015, background): “Many host-specific factors have been studied, including host species, genotype, diet and health (Rawls et al., 2006; Turnbaugh et al., 2006; Benson et al., 2010; Goodrich et al., 2014), as well as microbe-specific factors, including mutualistic and competitive interactions (de Muinck et al.”
Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation (2015, background): “Recent studies indicate that the gut microbiota can be considered an environmental factor that affects host adiposity and can contribute to obesity [11,12].”
Gut microbiota in health and disease. (2010, background): “In agreement with this, a significantly lower amount of energy remained in the feces of obese mice, relative to their lean counterparts, highlighting the increased capacity of the obese microbiome for energy extraction from the diet (313).”
The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota (2016, background): “Recently, the gut microbiota has gained great attention in metabolic diseases since gut dysbiosis has been demonstrated in obesity,((7,8)) MetS,((9,10)) diabetes,((11,12)) and cardiovascular diseases.”
Metagenomic biomarker discovery and explanation (2011, background): “Changes in microbial abundances in the gut, oral cavity, and skin have been associated with disease states ranging from obesity [15-17] to psoriasis [18].”