How RNA binding proteins interact with RNA: molecules and mechanisms

By M. Corley, Margaret C Burns, Gene W. Yeo. Molecules and Cells, 2020

657 citations recorded by the source corpus.

SUMMARY RNA binding proteins (RBPs) comprise a large class of over 2000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse. In this review we take a look at the components of protein-RNA interaction, from the molecular level to multi-component interaction. We first summarize what is known about protein-RNA molecular interactions based on analyses of solved structures. We additionally describe software currently available for predicting protein-RNA interaction and other resources useful for the study of RBPs. We then review the structure and function of seventeen known RNA binding domains and analyze the hydrogen bonds adopted by protein-RNA structures on a domain by domain basis. We conclude with a summary of the higher-level mechanisms that regulate protein-RNA interactions.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b2b5709f319a69d20f564b2d9015e8c7e0adf26f

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In Molecular Biology

Citations in the corpus

Transcription factors interact with RNA to regulate genes (2022, background): “TFs do not contain sequence motifs that resemble those of structured RNA-binding domains (Corley et al., 2020; Lunde et al., 2007) (Figure S3), so we searched for local amino acid features that might be common to TFs.”