The mouse Spo11 gene is required for meiotic chromosome synapsis.

By P. Romanienko, R. Camerini‐Otero. Molecules and Cells, 2000

783 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Recombinational DNA double-strand breaks in mice precede synapsis (2001, background): “Consistent with a conserved role in mammalian meiosis, meiocytes in Spo11 −/− mice are either asynaptic or have limited (frequently non-homologous) synapsis; males also exhibit an early prophase arres”
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis (2004, background): “The former include the oskar, vasa, nanos, tudor and germ cell-less genes (Rongo and Lehmann, 1996), and the latter include the piwi (Cox et al., 1998) and Yb (King et al., 2001) genes.”
Specific arrests of spermatogenesis in genetically modified and mutant mice (2004, background): “In male knock out mice, the pachytene stage is not reached and an abnormal zygotene dominates at which stage the cells arrest and enter apoptosis as confirmed histologically (Baudat et al., 2000; Romanienko and Camerini-Otero, 2000).”