Associative Learning Disrupted by Impaired Gs Signaling in Drosophila Mushroom Bodies

By J. B. Connolly, I. Roberts, J. Armstrong, K. Kaiser, M. Forte, Tim Tully, Cahir O'Kane. 1996

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Yoshinori Aso
2. N. Tanaka
3. Ronald L. Davis
4. Roger Cone
5. Seth M. Tomchik
6. K. Kaun
7. S. Waddell
8. H. Qin

Citations in the corpus

• Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, neutral): “Shafer, University of Michigan); OK107-Gal4 (Connolly et al., 1996); TH-Gal4 (Friggi-Grelin et al.”
• A family of octapamine receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster (2005, background): “…in the mushroom bodies, i.e. adenylate cyclase (rutabaga: Levin et al. 1992; Zars et al. 2000), phosphodiesterase (dunce: Chen et al. 1986; Dauwalder and Davis 1995), and a G protein (Gs: Connolly et al. 1996) severely impair or abolish the learning capability of fruit flies when mutated.”
• Origins of Cell-Type-Specific Olfactory Processing in the Drosophila Mushroom Body Circuit. (2017, unknown): “…A. Chiang, Wu et al., 2013 N/A Drosophila, Mz19-Gal4 Bloomington Drosophila Stock Center RRID: BDSC_34497 Drosophila, OK107-Gal4 Gift from K. Ito, Connolly et al., 1996 N/A Drosophila, UAS-ReaChR::Citrine in attP40 Bloomington Drosophila Stock Center RRID: BDSC_53741 Drosophila, UAS-mCD8::GFP in…”
• Competing dopamine neurons drive oviposition choice for ethanol in Drosophila (2013, background): “Disrupting neurotransmission in TH cells increased oviposition preference [n = 9–16 per strain; ANOVA: F(3,51) = 9.”
• Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory (2011, background): “1A) (Connolly et al., 1996; Aso et al., 2009), because the output synapses of these neurons are thought to undergo associative plasticity (Heisenberg, 2003; Gerber et al., 2004).”
• Mushroom body memoir: from maps to models (2003, result): “This result is consistent with the study of Connolly et al. 27 , who used the GAL4 enhancer trap technique to express, in the mushroom bodies, a constitutively active mutant Gα s -protein that is expected permanently to upregulate Rut-AC.”
• Dopamine and Octopamine Differentiate between Aversive and Appetitive Olfactory Memories in Drosophila (2003, background): “Attempts to localize olfactory memory in the Drosophila brain (Heisenberg et al., 1985; de Belle and Heisenberg, 1994; Connolly et al., 1996; Zars et al., 2000a,b; Dubnau et al., 2001; McGuire et al., 2001; Schwaerzel et al., 2002) have provided partial answers to these questions.”
• D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila (2007, background): “Flies with ablated MB structures or functions are completely defective in aversive learning (de Belle and Heisenberg, 1994; Connolly et al., 1996).”
• Cellular-resolution population imaging reveals robust sparse coding in the Drosophila Mushroom Body (2011, background): “, 2009) were crossed with OK107-Gal4 (Connolly et al., 1996) to drive GCaMP3 expression in essentially all KCs (Lee et al.”