Function and regulation of human copper-transporting ATPases.

By S. Lutsenko, Natalie L Barnes, M. Bartee, O. Dmitriev. Physiological Reviews, 2007

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Homeostasis and toxicology of essential metals (2012, background): “The human ATP7A gene product is a Cu-transporting P-type ATPase required for Cu absorption and homeostasis (Lutsenko and Petris, 2002; Lutsenko et al., 2007).”
Copper in plants: acquisition, transport and interactions. (2009, background): “Generally, many spliced products in humans show tissue-specific expression (Lutsenko et al. 2007).”
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “As copper accumulates, ATP7B shifts toward the apical membrane of polarized cells (Roelofsen et al., 2000; Guo et al., 2005; Lutsenko et al., 2007; Weiss et al., 2008).”
Copper: Toxicological relevance and mechanisms (2014, positive): “The Cu- ATPases are expressed in most tissues, and their transport activity is crucial for central nervous system development, liver function, connective tissue formation, and many other physiological processes (Lutsenko et al. 2007a, b).”
Copper homeostasis and cuproptosis in health and disease (2022, background): “In other tissues such as the placenta and the blood–brain barrier (BBB), ATP7A mediates the transport of Cu across polarized cells to ensure adequate Cu is delivered for the development of the fetus and brain.(32) In the liver, ATP7B mobilizes Cu in secretory vesicles to the bile in order to prevent”