Neural stem cell proliferation is decreased in schizophrenia, but not in depression

By A. Reif, S. Fritzen, M. Finger, A. Strobel, M. Lauer, A. Schmitt, Klaus-Peter Lesch. Molecular Psychiatry, 2006

650 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3b143d985ce872ddec9bcc799179217879ad2c88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. E. Gould
5. R. Hen
6. R. Duman
7. B. Leuner
8. S. Ge

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. R. Hen
5. E. Gould
6. B. Leuner
7. R. Duman
8. S. Ge

In Molecular Biology

1. Hongjun Song
2. Guo-li Ming
3. R. Hen
4. H. Schmidt
5. E. Gould
6. Li-Huei Tsai
7. B. R. Miller
8. B. Lu

Citations in the corpus

• Hippocampal plasticity in response to exercise in schizophrenia. (2010, background): “Abnormalities of olfactory neurons and of hippocampal granule cell neurons in schizophrenia indicate that impairment in adult neurogenesis could contribute to dysfunction of neural plasticity in schizophrenia.(3,4) Stimuli to modify olfactory neurogenesis in humans are unclear.”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Using immunohistochemistry to detect Ki-67, an endogenous marker of cell proliferation, one recent study found no significant difference between the rate of neurogenesis in the hippocampus from patients with MDD compared with healthy controls (Reif et al., 2006).”
• The current state of the neurogenic theory of depression and anxiety. (2015, background): “The first group found no difference between brains from control and depressed subjects [25], the second found a non-significant trend towards a decrease in progenitor cells in depressed patients [26], and the third group, using a different progenitor cell marker, found a significant decrease in prog”
• Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “, who based their conclusions on adult human neurogenesis on immunohistochemistry for proliferation marker Ki67 and studied 60 samples between 25 and 68 years, did not detect positive cells in all cases and found Ki67 up to 62 years ([52] and personal communication).”
• Structural Plasticity and Hippocampal Function (2010, background): “…can only be used to examine cell proliferation, they are useful when it is not feasible to deliver thymidine analogs, such as in the study of natural populations of animals (Amrein et al. 2004, Epp et al. 2009) or postmortem human tissue (Boldrini et al. 2009, Jin et al. 2006, Reif et al. 2006).”
• Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, background): “Interestingly, a recent study suggests that cell proliferation in the adult human dentate gyrus is decreased in schizophrenia, but not in depression (Reif et al., 2006).”
• DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009, background): “Decreases in neural stem cell proliferation have been reported in schizophrenia patients (Reif et al., 2006), and antipsychotics increase neurogenesis in the hippocampus (Newton and Duman, 2007).”