INAUGURAL ARTICLE: PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

By S. Yoo. 2004

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The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines (2011, background): “Both strains were crossed onto a PER2::luc background (8).”
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, methodology): “…36 C. Images were collected using an Olympus 43 XLFLUOR (NA 0.28) or UPlanApo (NA 0.16) objective and transmitted to a CCD camera (Spectral Instruments SI800, Tucson, AZ) cooled to 92 C. Signalto-noise ratio was improved by binning of pixels (838 for fibroblasts; 434 for dissociated SCN neurons).”
A circadian clock in macrophages controls inflammatory immune responses (2009, methodology): “A small piece of spleen, superficial inguinal lymph nodes as well as peritoneal macrophages from PER2::LUC knockin mice (20) were cultured in medium containing luciferin.”
RNA-methylation-dependent RNA processing controls the speed of the circadian clock. (2013, unknown): “These knockin mice carry an insertion of luciferase in phase with exon 23 of the Per2 gene (Yoo et al., 2004), making them invaluable to follow Per2 mRNA or protein processing in real-time.”