Desmoplastic Reaction in Pancreatic Cancer: Role of Pancreatic Stellate Cells

By M. Apte, S. Park, P. Phillips, N. Santucci, D. Goldstein, Rakesh Kumar, G. Ramm, M. Büchler, H. Friess, J. McCarroll and 4 more. Pancreas, 2004

605 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Rheumatology

View Paper: https://www.semanticscholar.org/paper/3a934e989d95d73beb13e59f04090166785d17ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. N. Bardeesy
2. D. Hanahan
3. Rakesh K. Jain
4. K. Strebhardt
5. A. Ullrich

In Immunology and Allergy

1. R. DePinho
2. N. Bardeesy
3. D. Hanahan

In Rheumatology

1. D. Hanahan

Citations in the corpus

• Targeting the TGFβ pathway for cancer therapy. (2015, background): “and TGFβ1 mediates the dialogue between PSCs and PDAC cancer cells (Apte et al., 2004).”
• The pancreatic stellate cell: a star on the rise in pancreatic diseases. (2007, background): “Activated PaSCs in the tumor desmoplasia of human pancreatic cancers express α -SMA and colocalize with mRNA encoding pro-collagen α 1 I (14) and are probably major contributors of the ECM proteins that constitute the desmoplasia (12, 14, 80–84).”
• Cancer-associated stromal fibroblasts promote pancreatic tumor progression. (2008, background): “for stroma production in both chronic pancreatitis and pancreatic cancer (5, 6, 28), few studies have used pancreatic stellate cells from human pancreatic adenocarcinoma samples due to the relative paucity of available fresh tumor specimens and the limited life span of primary cells.”
• Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. (2006, background): “F4/80, PMN, PDGFR , and MMP-9 expression was determined by counting the staining per field.”
• Stromal biology and therapy in pancreatic cancer (2010, background): “Upon activation by growth factors, cytokines or oxidant stress, PSCs transform into a myofibroblast-like phenotype and secrete excessive amounts of collagen I, III, fibronectin and matrix degrading enzymes such as MMPs.48 Figure 2 shows immunofluorescence stains of cultured primary human PSCs. Notab”