Natural RNA circles function as efficient microRNA sponges

By T. B. Hansen, Trine I. Jensen, B. Clausen, J. Bramsen, Bente Finsen, C. Damgaard, Jørgen Kjems. Nature, 2013

2,515 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3a6a1300d6c664422ceed16be7b2c9450158643c

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Citations in the corpus

Genomewide analysis of Drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation (2014, positive): “It contains $70 conserved target sites for miR-7, is bound by Ago proteins, and competes for miR-7 targeting (Hansen et al., 2013; Memczak et al., 2013).”
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development (2015, background): “There is increasing evidence that circular RNA is involved in biochemical pathways, including acting as miRNA sponges [2, 7] and binding proteins [2, 40].”
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (2016, background): “Due to their abundance and stability, circular RNAs are believed to be more effective relative to noncircular RNAs in sponging miRNA (1,7,9).”
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding (2013, positive): “Notably, recent work by the Rajewsky and Kjems groups has identified a lncRNA (CDR1as) that acts as an endogenous sponge for miR-7 (Hansen et al., 2013; Memczak et al., 2013).”
Expanded identification and characterization of mammalian circular RNAs (2014, background): “These numbers exceeded that of the other proposed miRNA sponge, mouse Sry, which has 16 miR-138 sites [9].”
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs (2016, background): “The main function described for circRNAs thus far in the literature is that of miRNA sponges, as shown for the circRNA ciRS-7, which has multiple binding sites for miR-7.(5) To RNA BIOLOGY 35”
lincRNAs: Genomics, Evolution, and Mechanisms (2013, positive): “…and repetitive regions were also found within the functional domains of Miat (Tsuiji et al., 2011), DBE-T (Cabianca et al., 2012), CDR1as/ciRS-7 (Hansen et al., 2013; Memczak et al., 2013), and other lincRNAs. lincRNA genes are preferentially found within 10 kb of proteincoding genes (Bertone…”
Comparison of circular RNA prediction tools (2015, background): “Aside from CDR1as/ciRS-7, which acts as a miR-7 sponge (7,14) and circMbl that acts as a decoy for its own protein product muscleblind (15), not much is currently known regarding the functional importance of circRNA.”