Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease.

By J. Segain, D. R. D. L. Blétière, A. Bourreille, V. Leray, N. Gervois, C. Rosales, L. Ferrier, C. Bonnet, H. Blottière, J. Galmiche. Gut, 2000

1,121 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/39ec95b1c0f695627e21769edf979b927598efa4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “Other studies suggest that n-butyrate inhibits nuclear translocation of NF-κB in certain cell types (34, 35).”
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment (2012, background): “Butyrate in particular is a major source of energy for colonocytes, but all three of these have demonstrated immunomodulatory properties [22-27].”
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. (2011, unknown): “…nutrition [101,102] IBD [53-65] Mucosal atrophy in radiotherapy or chemotherapy [101] Short bowel syndrome and intestinal failure [103] Prevention of colorectal cancer [46] Intestinal polyposis [104] Anti-inflammatory effect IBD [53-65] Pouchitis [105] Allergic colitis [106] Berni Canani R et al .”
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients (2008, background): “prausnitzii produces high amounts of butyrate, which has well known anti-inflammatory effects (13), we evaluated the effect of butyrate in Caco-2 reporter cell lines at the concentration present in the F.”
Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers (2018, background): “It may be protective against several diseases, including colorectal cancer (5), inflammatory bowel disease (6), graft-versus-host disease (7), diabetes (8), and obesity (8, 9).”
The Gut Microbiome Modulates Colon Tumorigenesis (2013, background): “Butyrate reduces inflammation (32) and inhibits growth and induces apoptosis in cancer cells (19, 20).”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Interestingly, a recent study found that TMAO induced the transcription of several genes encoding pro-inflammatory, atherosclerosis-promoting proteins in endothelial and smooth-muscle cells (but not peritoneal macrophages) through an unknown mechanism (Seldin et al., 2016).”