Label-Free, Single-Molecule Detection with Optical Microcavities

By Andrea M. Armani, R. Kulkarni, Scott E. Fraser, R. Flagan, K. Vahala. Science, 2007

1,130 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Biomedical Engineering, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/3939da0622a370eacb5e4254220e6da24bdd24e5

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In Atomic and Molecular Physics, and Optics

In Biomedical Engineering

In Electrical and Electronic Engineering

Citations in the corpus

Emerging applications of label-free optical biosensors (2017, methodology): “The exploitation of high-Q resonators to single-molecule label-free detection was demonstrated by a pioneering work carried out in CalTech [113] using a micro-ring resonator with Q > 108.”
Ligand–receptor interaction platforms and their applications for drug discovery (2012, background): “showed that WGM can detect single interleukin-2 molecules in serum, suggesting the potential of WGM for medical diagnostics [102].”
Single virus detection from the reactive shift of a whispering-gallery mode (2008, background): “The approach based on microspheres has advantages over other cavity geometries and label-free sensing mechanisms where a closed-form analysis of the wavelength shift signal may not be possible (13).”
Comparative advantages of mechanical biosensors (2011, background): “First efforts reported unprecedented ∼100 aM sensitivity with response times ∼1 s (ref”
Optical MEMS: From Micromirrors to Complex Systems (2014, background): “Biosensing [151], [152], optical frequency combs [153] and optomechanics [154] have attracted a lot of attention recently.”
Plasmonic Nanostructures for Nano-Scale Bio-Sensing (2011, background): “Single-molecule binding event leads to the shift of the resonant frequency [59].”
The photonic integration of non-solid media using optofluidics (2011, methodology): “Similar resonance concepts, albeit with more integration difficulty, are used in OFRRs, microtoroid and microsphere resonator”
Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation (2010, background): “To address these issues, researchers have turned to waveguide-based, monolithically integrated resonant interferometers, such as Bragg-grating-based Fabry–Perot resonators [6], microspheres [7], [8], microdisks [9], [10], microtoroids [11], photonic crystal cavities [12], and ring resonators [13]–[1”