Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD

By A. Baas, J. Boudeau, Gopal P. Sapkota, L. Smit, R. Medema, N. Morrice, D. Alessi, Hans Clevers. EMBO Journal, 2003

409 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/38f9c11d534fbad1008d499688a26830a700d772

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In Molecular Biology

1. D. Hardie
2. S. Hawley
3. D. Alessi
4. K. J. Mustard
5. R. Shaw
6. David M. Sabatini
7. David Carling
8. G. Steinberg

In Pathology and Forensic Medicine

1. D. Hardie

Citations in the corpus

• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 (2004, background): “its interaction with STRAD ( Baas et al, 2003 ) and MO25”
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade (2003, background): “Although STRAD and are related to the Ste20 protein kinases, several of the residues expected in active protein kinases are not conserved, and they appear to be inactive ‘pseudokinases’ [20].”