Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

By M. Krendel, F. Zenke, G. Bokoch. Nature Cell Biology, 2002

674 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/38a2ac040ce7b22eebe6728ec4ec7edb09ce6e3a

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In Cell Biology

1. Benjamin Geiger
2. A. Bershadsky
3. C. Waterman-Storer
4. Nathalie Q. Balaban
5. C. Der
6. K. Rossman
7. J. Sondek
8. B. Hinz

In Molecular Biology

1. K. Rossman
2. C. Der
3. Benjamin Geiger
4. Nathalie Q. Balaban
5. J. Sondek

Citations in the corpus

• GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors (2005, background): “Also, GEF-H1 interacts directly with microtubules and this interaction inhibits the exchange potential of GEF-H1 towards RhoA at the plasma membran”
• Conserved microtubule–actin interactions in cell movement and morphogenesis (2003, background): “Depolymerizing microtubules are thought to release the microtubule-bound Rho guanine nucleotide-exchange factor (GEF) GEF-H1 to activate Rho”
• Crosstalk of tight junction components with signaling pathways. (2008, background): “Upon microtubule depolymerization by nocodazol or thrombin treatment, GEF-H1 becomes active stimulating in consequence RhoA signaling [138,140].”
• Adhesion-dependent cell mechanosensitivity. (2003, background): “Its Rho-stimulating activity is low when it is in microtubule-bound state and high when it is free (Krendel et al. 2002).”