The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells.

By A. Izzo, Kinga Kamieniarz-Gdula, Fidel Ramírez, Nighat Noureen, Jop Kind, Thomas Manke, B. van Steensel, Robert Schneider. 2013

129 citations recorded by the source corpus.

Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genomic localization of all somatic replication-dependent H1 subtypes in human lung fibroblasts using an integrative DNA adenine methyltransferase identification (DamID) analysis. We find in general that H1.2 to H1.5 are depleted from CpG-dense regions and active regulatory regions. H1.1 shows a DamID binding profile distinct from the other subtypes, suggesting a unique function. H1 subtypes can mark specific domains and repressive regions, pointing toward a role for H1 in three-dimensional genome organization. Our work integrates H1 subtypes into the epigenome maps of human cells and provides a valuable resource to refine our understanding of the significance of H1 and its heterogeneity in the control of genome function.

Subfields: Molecular Biology

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Citations in the corpus

• Gene-specific H1 eviction through a transcriptional activator-p300-NAP1-H1 pathway (2019, background): “, 2009) and on correlations of chromatin occupancy with gene repression (Braunschweig et al., 2009; Izzo et al., 2013; Zhang et al., 2012).”