Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

By T. Outeiro, Susan Lindquist. Science, 2003

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Molecular pathophysiology of Parkinson's disease. (2005, background): “Studies in the model organism yeast further demonstrate that α-synuclein selectively associates with the plasma membrane, inhibits PLD activity, induces lipid droplet accumulation, and modulates vesicle trafficking (Outeiro & Lindquist 2003).”
Genetics of Parkinson disease: paradigm shifts and future prospects (2006, methodology): “Overexpression models of wild-type and mutant forms have been created in yeast, human cells, Caenorhabditis elegans , Drosophila melanogaster , mice and rat”
Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates (2005, background): “Recently, it has been shown that -syn is localized in the plasma membrane of yeast cells (Outeiro and Lindquist, 2003; Dixon et al., 2005), and the plasma membrane localization is affected by the mutations in the conventional secretory pathway (Dixon et al., 2005).”
Helix periodicity, topology, and dynamics of membrane‐associated α‐Synuclein (2005, background): “From the perspective of normal aS function, this repeat lies in the middle of a region that was recently demonstrated to be important for inhibition of PLD2 (Payton et al. 2004), one of the few well-documented functional roles of aS (Jenco et al. 1998; Ahn et al. 2002; Outeiro and Lindquist 2003).”