Genetics of Parkinson disease: paradigm shifts and future prospects

By M. Farrer. Nature reviews genetics, 2006

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Missing pieces in the Parkinson's disease puzzle (2010, background): “They account for 2–3% of the late-onset cases and ∼50% of early-onset form”
A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes (2009, neutral): “Denervation of dopaminergic neurons in the substantia nigra (SN) results in severely debilitating motor symptoms such as bradykinesia, resting tremor and rigidity (Farrer, 2006; Fearnley and Lees, 1991).”
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “Our understanding of the molecular events in PD pathogenesis has been greatly advanced by the identification and analysis of PD-associated genes (Farrer, 2006).”
VPS35 mutations in Parkinson disease. (2011, background): “Studies of familial parkinsonism have identified pathogenic mutations in several genes, and such identifications have provided mechanistic insight and novel targets for therapeutic intervention.(3) These loci have been associated with idiopathic PD, emphasizing the importance of studying monogenic f”
Parkinson's disease and parkinsonism: neuropathology. (2012, background): “The exclusion criteria also include absence of family history of movement disorder, but this is criterion is often ignored today given increasing evidence of genetic determinants of PD (Farrer 2006).”