Inflammasome complexes: emerging mechanisms and effector functions

By Vijay A. K. Rathinam, Katherine A. Fitzgerald. Cell, 2016

963 citations recorded by the source corpus.

Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery, and the full spectrum of inflammasome functions, extending their influence beyond canonical functions, to regulation of eicosanoid storm, autophagy and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/3828cdd1b0d2cbbf796313474b3fbf7e645d5ecb

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Citations in the corpus

Metabolic Instruction of Immunity (2017, positive): “Inflammasome activation increases tissue inflammation through IL-1β and IL-18 secretion via cleavage activation by caspase-1 and pyroptosis (Rathinam and Fitzgerald, 2016).”
Adeno-associated virus as a delivery vector for gene therapy of human diseases (2024, background): “430 The ligands for IL-1R are IL-1 α and IL-1 β , which are activated following in ﬂ ammasome activation, 431,432 while MyD88 acts downstream of TLRs and IL-1R.”
A guide to cell death pathways (2023, neutral): “The downstream signalling of these complexes is determined in both a PRR-dependent and stimulus-dependent manner 209 .”
Pattern recognition receptors in health and diseases (2021, background): “The inflammasome signaling Inflammasome is the multi-protein complex assembled by PRRs in the cytoplasm and is an important part of the innate immune system.(295) The inflammasome can recognize PAMPs or DAMPs and recruit and activate Caspase-1.”
Autophagy-Independent Functions of the Autophagy Machinery (2019, background): “One of the substrates of non-conventional secretion is mature interleukin 1 beta (IL1B, best known as IL-1b), which is produced in the cytosol of cells with pro-inflammatory activity (like macrophages) upon proteolytic maturation of the IL-1b precursor by the NLRP3 inflammasome (Rathinam and Fitzger”