Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space.
By Derick Han, Everett Williams, E. Cadenas. Biochemical Journal, 2001
615 citations recorded by the source corpus.
Subfields: Biophysics, Electrochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/382290a402b7fdab8dc11e481b5c75d12265dc60
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Citations in the corpus
- Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, positive): “Complex I superoxide is released nearly exclusively to the matrix side of the inner membrane, whereas complex III likely generates superoxide to both the matrix and outward to the intermembrane and extramitochondrial space (128, 299).”
- The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology (2001, background): “A recent study with suitable spin traps, however, revealed superoxide formation in mitoplasts ( 5 ).”
- Body size, energy metabolism and lifespan (2005, background): “Ubisemiquinone, however, may donate its electron to oxygen generating ROS on the inter-membrane side of the complex (Han et al., 2001).”
- Crosstalk between mitochondria and NADPH oxidases (2011, background): “The main sources of mitochondrial ROS under physiological conditions are complexes I and II, which produce O2 mainly on the matrix side, where it is rapidly dismutated to H2O2 by mitochondrial manganese superoxide dismutase (SOD2) [30,31].”
- The sites and topology of mitochondrial superoxide production (2010, neutral): “1) (Han et al., 2003; Han et al., 2001; Miwa and Brand, 2005; Miwa et al., 2003; Muller et al., 2004; St-Pierre et al., 2002).”
- Trends in oxidative aging theories. (2007, background): “This latter localization is likely of considerable biological importance because the mitochondrial electron transport chain can release superoxide into that compartment [50,183,184].”