Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

By I. Conboy, M. Conboy, G. Smythe, T. Rando. Science, 2003

1,139 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/37cc80e56ad7d0cae3aead2427dc5ca9c18c19c9

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Satellite cells and the muscle stem cell niche. (2013, background): “However, the induction of Delta in myofibers is no longer responsive to muscle injury, which results in reduced satellite cell proliferation and impaired muscle regeneration (107).”
The aged niche disrupts muscle stem cell quiescence (2012, background): “The signalling cascades responsible for regenerative decline in aged muscle have been intensely investigated 9,11,15 , in contrast, the mechanisms driving SC depletion with age remain unknown.”
Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts (2008, background): “et al., 2001) and muscle precursor cells ( Conboy et al., 2003 ).”
Mechanisms of stem cell self-renewal. (2009, background): “Cell-extrinsic changes that regulate changes in stem cell function during aging have been studied in muscle, where Notch ligand expression declines with age, reducing Notch activation in satellite cells and muscle regenerative capacity (Conboy et al. 2003).”
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells (2010, methodology): “Myofiber-associated cells were prepared from intact limb muscles (extensor digitorum longus, gastrocnemius, quadriceps, soleus, traverus abdominis and triceps brachii) as described previousl”
The Skeletal Muscle Satellite Cell: The Stem Cell That Came in From the Cold (2006, background): “That said, exposure of myogenic progenitors from old muscle to a young environment rejuvenates the capacity of progenitors to contribute to repair (Carlson and Faulkner 1989; Carlson et al. 2001; Conboy et al. 2005) indicating that (some?) satellite cells do not change significantly with age.”
Satellite Cells and Skeletal Muscle Regeneration (2015, neutral): “Importantly, it has been shown that aged muscles fail to increase levels of the Notch ligand Delta during muscle injury (68).”