Lipid II as a target for antibiotics

By E. Breukink, B. Kruijff. Nature reviews. Drug discovery, 2006

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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies (2006, background): “In the case of the lantibiotics, the concept of combining several antibiotic activities in one molecule has permitted the achievement of unprecedented potencies as demonstrated by, for example, nisin, gallidermin and lacticin 3147 (ref”
New antibiotics from bacterial natural products (2006, background): “Availability of lipid II is thought to be a bottleneck for cell wall formation—as few as 2,000 lipid II molecules per cell are estimated to engage in the cycl”
Inhibitory activity of probiotics Streptococcus phocae PI80 and Enterococcus faecium MC13 against Vibriosis in shrimp Penaeus monodon (2009, result): “Similar observation was made by Abee et al. (1994) and Breukik and de Kruijff (2006) .”