Human polymorphism at microRNAs and microRNA target sites

By M. A. Saunders, Han Liang, Wen-Hsiung Li. Proceedings of the National Academy of Sciences of the United States of America, 2007

650 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/37968a7894f2191221bad9965545d3ce06ee3655

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Citations in the corpus

MicroRNAs in body fluids—the mix of hormones and biomarkers (2011, positive): “Although SNPs are rare in miRNA genes, they can affect miRNA function in pri-miRNA transcription, pri-miRNA and pre-miRNA processing, and miRNA binding sites”
RNA regulons: coordination of post-transcriptional events (2007, background): “A single miRNA species can also target multiple mRNAs, and combinations of miRNAs and RBPs probably dictate the coordinated outcomes of post-transcriptional gene expression by interacting with multiple USER”
Genetic variation in microRNA networks: the implications for cancer research (2010, positive): “Since then, several studies have used systematic sequencing or in silico approaches to identify SNPs in miRNA-related genes, catalogues of which have been created and made publi”
Evolution of microRNA diversity and regulation in animals (2011, background): “Although there is strong negative selection against changes in miRNA target site”
PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways (2013, background): “(3) Using context+score to assess polymorphic miRNA–mRNA interactions.”
A SNP in a let-7 microRNA complementary site in the KRAS 3′UTR Increases Non-Small Cell Lung Cancer Risk (2008, background): “MiRNAs bind to the 3¶ untranslated regions (UTR) of their target genes, regions which are evolutionarily highly conserved (2, 3), suggesting an important role for these regions in natural selection.”
Pervasive roles of microRNAs in cardiovascular biology (2011, background): “Although mutations within the seed regions of evolutionarily conserved miRNAs are not common, single nucleotide polymorphisms (SNPs) within miRNA-binding sites in the 3′ UTRs of target mRNAs have been observed at a higher frequenc”
MicroRNAs in stress signaling and human disease (2012, background): “In general, SNPs are underrepresented within miRNA-encoding loci, which is consistent with negative selection acting on these sequences (Saunders et al., 2007).”