Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.

By E. Leslie, R. Deeley, S. Cole. Toxicology and Applied Pharmacology, 2005

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Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “Elevated expression of MRP1 has been observed in a variety of hematological and solid tumors, and increased expression levels of other MRP transporters are found in a few cancerous tissues (Leslie et al., 2005; Deeley et al., 2006).”
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions (2006, background): “In addition to structural elements assuring tightness of the BBB, transport systems and drug-metabolizing enzymes (including cytochrome P450 hemoproteins and uridine diphosphate glucuronosyltransferases) provide an enzymatic barrier (Lee et al. 2001; Leslie et al. 2005).”
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. (2006, background): “Similarly, MRP1 in the placenta may protect the developing fetus from xenobiotics and help prevent the fetal accumulation of endobiotics, such as E217 G (287, 479).”
ABC multidrug transporters: structure, function and role in chemoresistance. (2008, background): “It protects tissues such as the bone marrow, kidney collecting tubules, and oropharyngeal and intestinal mucosa, from toxicants, and is also involved in drug clearance from the cerebrospinal fluid, testicular tubules and peritoneum [13].”