Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

By S. Finotto, Markus F. Neurath, J. Glickman, S. Qin, H. Lehr, F. Green, Kate G. Ackerman, K. Haley, Peter R. Galle, S. Szabo and 3 more. Science, 2002

682 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/37629327d40c69c240afbe4e66fe7b2ae189fe1c

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In Immunology

In Physiology

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Citations in the corpus

Decision making in the immune system: The lineage decisions of helper T cells (2002, neutral): “and their predisposition to allergic airway diseas”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “Consistent with this idea, Tbx21 ⁄ ) mice have been reported to develop spontaneous airway hypersensitivity and T-betexpressing CD4 T cells in asthmatic patients are reduced in frequency (108).”
The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, result): “Consistent with the prominent role of Th2 cells in asthma, T-bet expression is reduced in T cells from the airways of asthmatic patients compared with airway T cells from nonasthmatic patients (21).”
The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease (2002, methodology): “2–4-mo-old Balb/c and B6 mice were obtained from the central breeding facility at the University of Mainz or from Charles River Laboratories; S129/B6 wild-type and STAT1–deficient mice (38) were obtained from Taconic; T-bet knockout mice and transgenic mice expressing T-bet in T cells under the cont”
Differentiation of Effector CD4 T Cell Populations (2010, neutral): “T-bet-expressing CD4 T cells are dramatically reduced in human asthmatic airways, and Tbx21−/− mice spontaneously develop airway hypersensitivity (68).”
TGF-beta: a master of all T cell trades. (2008, positive): “, 2006a), consistent with a function of T-bet in promoting Th1 and suppressing Th2 cell differentiation (Finotto et al., 2002).”